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Diazepam, first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.
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It is commonly used for treating anxiety, insomnia, seizures, muscle spasms, restless legs syndrome, alcohol withdrawal, benzodiazepine withdrawal, and Ménière's disease.
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It may also be used before certain medical procedures (such as endoscopies)
Dosages should be determined on an individual basis, depending upon the condition to be treated, the severity of symptoms, the body weight of the patient, and any comorbid conditions the patient may have.
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Typical dosages for healthy adults range from 2 mg per dose to 10 mg per dose taken 2 to 4 times per day, depending on such factors as body weight and condition being treated. For the elderly or people with liver disorders, initial dose is at the low end of the range, with the dose being increased as required.
Diazepam is a core medicine in the World Health Organization's "Essential Drugs List," which is a list of minimum medical needs for a basic health care system. Diazepam is used to treat a wide range of conditions and has been one of the most frequently prescribed medications in the world for the past 40 years. It was first synthesized by Dr. Leo Sternbach.
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