Crystallisation Scale-up
On September 24 and October 1, Mark Barrett of the Ireland-based Solid State Pharmaceutical Cluster will present a free webinar series: Optimisation and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallisation Process.
Part 1 of the Optimisation and Scale-up of a Hydrodynamically Limited Antisolvent Crystallization Process webinar series presents the crystallisation optimisation protocol. Certain attributes of turbulent mixing have been identified to impact key crystallisation characteristics, such as the metastable zone width (MSZW), primary and secondary nucleation events, growth and agglomeration rates. This section focuses on the use of PAT and CFD in understanding these common industrial crystallisation challenges and in turn facilitates the production of methods for the scale-up and scale-down of the crystallisation process.
Part 2 of webinar series takes the developed protocol to a scale-down and scale-up environment and demonstrates how crystal nucleation, growth and dimension can be maintained on scale. This approach highlights the necessity for a link to be forged between crystal size, form, kinetics, etc. and the attained mixed environment. In turn, a platform is produced to facilitate the right first time crystallisation scale-up, tech transfers and scale-down assessments of this hydrodynamically limited process.
The presenter, Mark Barrett, will base the webinar series on an award winning presentation he gave at the METTLER TOLEDO 16th International Process Development Conference. Mark received his Ph.D. from University College Dublin (UCD). Mark's thesis focused on crystallisation development and scale-up. Previously, Mark worked for Schering-Plough as a Process Development Engineer. Mark is now a Senior Research and Development Engineer at the Solid State Pharmaceutical Cluster (SSPC).
Photo:
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