Biodetection Technologies - Technological Responses to Biological Threats

PRLog (Press Release) – Apr 22, 2008 – With an emphasis on rapid detection and low-cost identification, this publication provides solutions to the challenges presented by the evolving pattern of complex biological threat agents of various origins. Important topics addressed include:

Biothreat Sensing, Detection and Identification
Biomarker Discovery
PCR and non-PCR Detection Technologies
Micro- and Nanoscale Technologies
On-A-Chip Detection Technologies
Fluorescence-Based Detection Systems

Chapter 1

Requirements of Biosensor Technologies by Municipal Water Laboratories: Pathogens of Interest and Hardware Requirements
Tammy A. Spain, PhD, Senior Chemist/Technical Director of Microbiology, Analytical Division, Pinellas County Utilities Laboratory
Most of the biosensor technologies available on the market have the potential to test water for pathogens. Yet municipal water systems have been extremely challenging markets for biosensors. This presentation will provide an overview of biosensor technologies that might be useful to municipal water facilities, the types of pathogens and indicators that water laboratories are generally interested in detecting and hardware requirements for biosensors that may potentially be used in a municipal water laboratory.

Chapter 2

Biosensor Format and Technological Backbone for a “National Biodefense & Pandemie Immune System”
Peer F. Stähler, PhD, Vice President and Chief Scientific Officer, febit biotech GmbH, Germany
The unforeseeable nature of biodefense and pandemic threats suggest the development of a “National biodefense & pandemie immune system”. The technological backbone we propose provides: Fast and sensitive detection, ability to rapidly adapt and distribute tests, and decentralized test production to reduce vulnerability. A network of production sites feeds another network of analyzers. The components of this system are with units for flexible synthesis and instruments for analysis of high-speed microfluidic biochips equipped with microarrays of superb quality and 3’-oligos to enable polymerase based signaling.

Chapter 3

Current Advances in HTP DNA Sequencing Technologies
Kenton L. Lohman, PhD, Senior Biotechnology Advisor, MRI Mid Atlantic Operations, Midwest Research Institute
HTP sequencing technologies have begun to reach commercial fruition and to accelerate the discovery of biodiversity across many species. Technological approaches vary from conventional amplification-based sample preparations to single molecule microchip platforms. The application of these new technologies to Biodefense is driving biomarker discovery for diagnostics, vaccines, and therapeutics to defend against natural or engineered biological threats.

Chapter 4

Development of Assays and Qualified Reagents in Support of Biothreat Agent Detection
Kurt J. Langenbach, PhD, Assay Development Scientist, ATCC/Biodefense & Emerging Infections Research Resources Repository
Our program focuses on implementing increasingly rigorous levels of authentication and characterization to help establish standard reference biothreat organisms and nucleic acids. Assays and techniques that establish specimen identification, concentration, purity, functional activity and preservation/viability are evaluated. These may include biochemical profiling (using traditional and automated platforms), genetic profiling (such as sequencing, genome fingerprinting or PCR) and functional profiling (such as antibody reactivity/neutralization, or CPE). Our goal for these products and techniques is to extend the researcher’s ability to develop new technologies by enhancing the accuracy of pathogen identification.

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