Trevigen Launches Anti-8-oxo-dG Monoclonal Antibody (Clone 2E2)

PRLog (Press Release) - Mar 07, 2008 -
DNA damage caused by oxidative radicals is associated with aging, inflammation, carcinogenesis, Parkinson’s and Alzheimer’s diseases. When exposed to oxidative radicals, 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) is formed and can serve as a sensitive indicator of physiological and environmental damage to DNA. This
mouse monoclonal antibody specifically binds to 8-hydroxy-2’-deoxyguanosine within DNA in H2O2-treated cells.

It can be used to detect oxidative damage by ELISA and immunocytochemistry. For optimal outcomes, cells should be grown on a surface that allows for fixation and direct labeling such as sterile chamber slides and coverslips. This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.

Sufficient antibody is provided for approximately 50 slides, when a 1:250 dilution is used (Cat# 4354-MC-050). For details, contact Trevigen by phone at 800-873-8443, by email info@trevigen.com or visit the website www.trevigen.com.