rPeptide Introduces Amyloid precursor proteins

PRLog (Press Release) – Feb 26, 2008 – (i)Beta-Amyloid Precursor Protein, CTF-31
MW: 3717.1 Da
H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 740-770
Description:
Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 31-amino acid peptide, results from the proteolytic cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Asp739-Ala740 by caspases. Reported to induce apoptosis and may be involved in the neuronal death associated with Alzheimer’s disease, either via amplifying caspase activation or by the selective increase in Abeta 42 production.
References:
Dumanchin-Njock, C., et al. 2001. J. Neurochem. 78, 1153
Soriano, S., et al. 2001. J. Biol. Chem. 276, 29045
Gervais, F.G., et al. 1999. Cell 97, 395
LeBlanc, A., et al. 1999. J. Biol. Chem. 274, 23426.
For more info
http://www.rpeptide.com/products/db_images/A-1201,%20APP ...

(ii)Beta-Amyloid Precursor Protein, CTF-50




MW: 5910.7 Da
H-Val-Met-Leu-Lys-Lys-Lys-Gln-Tyr-Thr-Ser-Ile-His-His-Gly-Val-Val-Glu-Val-Asp-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 721-770
Description:
Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 50-amino acid peptide, results from the γ-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Leu720-Val721. May also serve as one of the precursors for the generation of the toxic C31 fragment of APP (Cat. No. A-1201)
References:
Gu, Y., et al. 2001. J. Biol. Chem. 276, 35235
Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481
Lu, D.C., et al. 2000. Nat. Med. 6, 397
http://www.rpeptide.com/products/db_images/A-1202,%20APP ...
(iii)Beta-Amyloid Precursor Protein, CTF-57

MW: 6650.7 Da
H-Thr-Val-Ile-Val-Ile-Thr-Leu-Val-Met-Leu-Lys-Lys-Lys-Gln-Tyr-Thr-Ser-Ile-His-His-Gly-Val-Val-Glu-Val-Asp-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH; APP 714-770
Description:
Lyophilized solid; TFA salt; Purity > 95% packed under inert gas; hygroscopic; light sensitive. A 57-amino acid peptide, results from the γ-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Ala713-Thr714. Represents CTFg fragment naturally generated in conjunction with Abeta42. May also serve as one of the precursors for the generation of the toxic C31, fragment of APP (Cat. No. A-1201)
References:
Gu, Y., et al. 2001. J. Biol. Chem. 276 , 35235
Pinnix, I., et al. 2001. J. Biol. Chem. 276, 481
Yu, C., et al. 2001. J. Biol. Chem. 276, 43756
For more info:
http://www.rpeptide.com/products/db_images/A-1203,%20APP ...