These structures and their chemical make up offer targets
for antiviral agents. The generally accepted hypothesis on mechanisms of inactivation is based on whether viruses are lipophilic (enveloped viruses such as herpes simplex) or hydrophilic (naked or non-enveloped viruses such as poliovirus).
The active ingredient of the AEM 5700/5772 Antimicrobial has been tested in solution and on treated surfaces against a small range of viruses. Following are summaries of this work:
A series of tests were run at Hill Top Research, Cincinnati, Ohio using a 1% solution of AEM 5700. The test method used was designed for disinfectant products used on an inanimate environmental surface for compliance with US EPA Pesticide Assessment Guidelines, Subdivision G: Product Performance, November, 1982. Viricidal activity was shown against Herpes simplex type 1, an enveloped virus).
Poliovirus Type 2
In a static test run by Southern Research Institute, Birmingham, Alabama surfaces treated with the active ingredient of AEM 5700 showed viricidal activity against Poliovirus type 1 (Strain MEF-
1) (a non-enveloped RNA enterovirus.
Bacteriophage T2 and Herpes Simplex Type 1
In a series of experiments and papers I-Fu (Eric) Tsao and Henry Y. Wang of the University of Michigan, Ann Arbor, Michigan tested the antiviral activity of AEM 5700 treated alginate beads in a flow through filtration system. Antiviral activity against bacteriophage T2 and herpes simplex virus type 1 (HSV-1) (an enveloped animal virus) was shown both in the presence and absence of proteins in the test solutions.
Numerous papers have been written on the antiviral activity of standard quaternary ammonium compounds both in solution and when immobilized on inert supports.
These papers show inactivation of lipid-containing viruses, some non-lipid viruses, and bacteriophages. No antiviral activity was shown for smaller non-lipid viruses such as piconaviruses
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AEM 5700 solutions and AEM 5700 treated surfaces show positive antiviral activity against a range of viral types. These results are encouraging regarding the utility of this treatment at reducing doses of viruses in a variety of applications.
Interest in the potential activity of the AEM 5700 solution on treated surfaces against specific viruses must be pursued with specific tests.
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