AnaSpec Introduces Acetylated and Methylated Lysines

PRLog (Press Release) – July 23, 2007 – San Jose, CA
AnaSpec has introduced acetylated, mono-methylated, di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The use of these building blocks, although not limited to making synthetic histone peptides, provides additional tools for researchers to help unravel the “histone code.”5
The lysine-rich amino terminal tail of the core histones undergo posttranslational modifications such as acetylation and methylation.1-2 Addition of acetyl group or 1 to 3 methyl groups occur at position specific lysines.3-4 These modifications, as well as phosphorylation of serine residues and others, serve to differentially regulate chromatin activity.5
Acetylated Lysines
Fmoc-Lys(Ac)-OH
Boc-Lys(Ac)-OH

Methylated Lysines
Fmoc-Lys(Me, Boc)-OH
Fmoc-Nε,ε-dimethyl-L-lysine hydrochloride salt
Boc-Nε,ε-dimethyl-L-lysine hydrochloride salt
Fmoc-Lys(Me)3-OH chloride

Phosphorylated Serines
Fmoc-Ser[PO(OBzl)-OH]-OH
Fmoc-D-Ser[PO(OBzl)-OH]-OH

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Company Info

AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and combinatorial chemistry. Established in 1993, AnaSpec's ISO9001:2000 certified headquarters and manufacturing facilities are located in San Jose, CA.
For more information, visit www.anaspec.com
References:
1.   Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
2.   Talasz, H. et al. J. Biol. Chem. 280, 38814 (2005).
3.   Schotta, G. et al. Genes Dev. 18, 1251 (2004).
4.   Paik, Wk. and S. Kim, Science 174, 114 (1971).
5.   Strahl, BD and CD. Allis, Nature 403, 44 (2000).