Homo-Amino Acids Provide Novel Options for Drug Discovery

PRLog (Press Release) - Oct 16, 2006 -
An example is shown in Shimizu’s paper3 where certain amino acids in the parathyroid hormone peptide PTH (1-14) have been substituted with Aib (aminoisobutyric acid) and homoarginine. This shorter N-terminal fragment is found to be as potent as PTH (1-34) for stimulating cAMP formation in PTH-1 receptor-expressing cells.

AnaSpec, a leading provider of integrated proteomics solutions, provides a source of homo-amino acids suited for either drug discovery or investigation of peptide biological activity.

Homo-Amino Acids:
· Fmoc-homoarginine(Pbf)-OH
· Fmoc-S-trityl-L-homocysteine
· Boc-S-trityl-L-homocysteine
· Fmoc-L-homophenylalanine
· Fmoc-D-homophenylalanine
· Fmoc-homoproline-OH or Fmoc-Pip-OH
For more information visit www.anaspec.com

References:
1. Internet. http://www.chem.qmul.ac.uk/iupac/AminoAcid/AA1n2.html#AA23/ Sept. 27, 2006.
2. IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC). Nomenclature of Organic Chemistry, Section F: Natural Products and Related Compounds, Recommendations 1976, Eur. J. Biochem. 86, 1 (1978).
3. Shimizu, N. et al. J. Bone & Mineral Res. 19, 2078 (2004).